Isa Brancatisano began her basketball journey with Melbourne Tigers at junior level and gradually progressed to play for the West Coast Waves in the old South East Australian Basketball League (SEABL) in 2014.

She went on to achieve success in 2017, winning the title with Geelong Supercats. She also had impressive campaigns with the Ballarat Miners before eventually landing with the Mount Gambier Pioneers as the competition transitioned into being the NBL1 South.

In the past three seasons for the Pioneers, Isa has excelled, winning the league's Defensive Player of the Year honours in 2023. Her steady performance earned her a contract with the Sydney Flames for the 24/25 WNBL season, which included a career best 26-point (sparked by 8 three pointers) performance against the UC Capitals to send the Flames to the playoffs.

This season, Isa brings her trademark 3-and-D package to the Caps and hopes to help the side end a three-season playoff drought.